No oral insulin, but some t2ds can keep their blood sugar in “range” with just oral medicine.
i.e. the early t2ds whos bodies are still responsive to the insulin their pancreas is producing and are teetering on the edge… so when metformin down regulates gluconeogenesis and upregulates glut4 transporters it can be just enough to avoid hyperglycemia
Think of it as the last hail Mary of the prediabetic
No oral insulin, but some t2ds can keep their blood sugar in “range” with just oral medicine.
i.e. the early t2ds whos bodies are still responsive to the insulin their pancreas is producing and are teetering on the edge… so when metformin down regulates gluconeogenesis and upregulates glut4 transporters it can be just enough to avoid hyperglycemia
Think of it as the last hail Mary of the prediabetic