I think it depends on the vape (and ingredients) in question. Cannabis vapes from dispensaries are required to not have additives. They’re all tested thoroughly. So those would be “safer” than things with added oils or flavoring. I’m not sure if they’re better than vaporizing the actual plant flower instead of concentrate.

Nicotine based vapes, I can only assume use some interesting ingredients since it’s not just a compressed/heated/iced tobacco plant. I’ve never used one, but I’ve also never seen someone ask for test results of a nicotine vape (or have them provided).