VMware vSAN cluster, ceph cluster, building HA for different services, containers, k8s cluster. The list goes on.

TrueNAS is an option. However, I am not sure if you can configure active-active cluster with it. As for VMware vSAN, you can place a Witness on a small device (e.g. Raspberry PI). It is a nice option for a homelab. https://williamlam.com/2020/10/vsan-witness-using-raspberry-pi-4-esxi-arm-fling.html

Since you already have Starwinds licenses, I would go for it. 2 node cluster on top of ESXi works great. We have customers using it with no issues.

It should do a great job. I’ve just finished my new build for Jellyfin (migrated from Plex). I have i3-12100 and 32GB of RAM and Jellyfin works great on it.

I haven’t heard about Cosmo. I need to test it. Thanks for sharing.