

Oh, hello! And welcome :)
Do you know the concentration? That is, how many mg of estradiol you are using?
I wouldn’t expect to see much effect from E per se at three weeks, especially if it’s a low dose, but one of the first things to look for would be nipple sensitivity. If your T is suppressed, you’ll get a noticeable drop in libido and body odor pretty quickly.
Oh, that’s a sucky betrayal and I feel for you. Have a virtual hug <3