From this panel discussion https://youtu.be/1cl2IX94GCI

A Dr. John McDougall posits that T2D is caused by fat clogging insulin receptors, and that white sugar and rice can reverse T2D.

A Dr. Michael Klaper Says that if your eating a whole food plant based diet nothing will shoot your blood sugar up

Dr. John McDougall references this paper https://www.nejm.org/doi/full/10.1056/NEJM197103112841004 where sugar is increased in t2d to give greater glycemic control “Sugar makes insulin better and cures diabetes” !?!??!?!?!?!?

I can’t find the full paper just the abstract.

Question: How on earth does any of this work and is this speaker credible?

As far as I understand it T2D is a syndrome of insulin resistance which has caused very poor glycemic control, so the patient is effectively carbohydrate intolerant.

This speaker suggests that increasing sugar intake when carbohydrate intolerant improves glycemic control, and reverses T2D… what? What?

I feel like I’m taking crazy pills.

  • jetOPA
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    1 day ago

    Ok, I never really got a answer to this question so its been sitting in the back my of my head for a long time. I’ve stumbled across a plausible explanation

    The Randall cycle : A cross inhibition between glucose and fatty acid metabolism in every cell. When both high glucose levels and high fatty acid levels exist at the same time the Randle cycle causes the cell to rapidly fluctuate between both method, which does cause stress and inflammation in the cell… now some handwaving… this is manifested as insulin resistance (i.e. the cell can’t update more glucose because of the Randle cycle inhibition)

    Now… this is a CROSS inhibition… so if you remove one of the sources (glucose, and fatty acids) then the Randle cycle just stays in one mode and you don’t get the seesaw inflammation.

    This would account for the all starch diet being able to fix insulin resistance (no free fatty acids). It’s a mechanistic explanation that works for me. i don’t understand it fully, but it seems to fit.

    Obviously going all glucose isn’t super healthy, and I wouldn’t recommend it, but it has been a puzzle on why it works in some circumstances.

    i.e. https://www.youtube.com/watch?v=OlsjnLMANDQ