Harvard-trained physician-scientist Dr. Nick Norwitz joins me to unpack the real drivers of metabolic health. He shares how keto sent his severe ulcerative colitis into remission within one week, why “calories in, calories out” is a dead-end tautology, what happened when he overfed ~6,000 calories/day and didn’t gain weight, and how medical training ignores nutrition while Big Food-friendly myths persist. We hit CGMs in med-ed, GLP-1s, statins’ surprising effects on GLP-1, funding unbiased metabolic research, and whether long-term keto is not just therapeutic but optimal.

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Why Doctors Aren’t Taught Nutrition — Dr. Nick Norwitz Exposes The Truth

Participants: Dr. Eric Westman (host) and Dr. Nick Norwitz (guest)

Norwitz’s background & health story

  • Undergraduate at Dartmouth (cell biology & biochemistry); PhD at Oxford; admitted to Harvard Medical School.
  • Developed severe inflammatory bowel disease with debilitating GI symptoms.
  • Attempted standard medical approaches without adequate relief.
  • Adopted a Mediterranean-leaning ketogenic diet (fatty fish, olive oil, vegetables; low carbohydrate) and experienced rapid, substantial improvement and recovery.

Why doctors aren’t taught much nutrition

  • Medical training is designed primarily for diagnosing and treating disease with medications and procedures; prevention and nutrition receive little curricular time.
  • “Evidence-based medicine” is valuable but can be limited by:
    • Overreliance on narrow hierarchies that discount mechanistic and patient-level evidence.
    • Institutional incentives (e.g., drug-centric frameworks) that don’t translate well to diet and lifestyle.
  • Practical nutrition education is often missing, leaving clinicians without clear frameworks or tools.

Models of obesity & metabolism discussed

  • Calories In/Calories Out (CICO): Critiqued as a near tautology—describes weight change but offers limited mechanistic guidance.
  • Carbohydrate-Insulin Model (CIM): Presented as an alternative framework emphasizing hormonal regulation (insulin) and carbohydrate quality/quantity as drivers of fat storage and appetite.

Clinical practice considerations raised

  • Many patients achieve meaningful improvements (weight, metabolic health) with low-carb/keto patterns; individual responses vary.
  • Randomized trials and mechanistic studies both matter, but patients ultimately need safe, n=1 experimentation with clinician support.
  • Clinicians are comfortable prescribing FDA-approved drugs (e.g., GLP-1 agonists, SGLT2 inhibitors), but comparable, scalable guidance for nutrition is rarely taught despite potential benefit.

Statins, GLP-1, and emerging evidence

  • A highlighted human controlled trial reported that statin therapy markedly reduced circulating GLP-1 levels over ~16 weeks, raising questions for primary prevention scenarios with isolated LDL elevation.
  • Framed as hypothesis-generating rather than definitive clinical guidance; underscores the need for open, nuanced discussion about trade-offs.

Westman’s reflections (host)

  • Early clinical encounters with patients succeeding on very low-carb or carnivore-leaning diets challenged prior assumptions.
  • Longstanding experience suggests such diets can be safe and effective for many, but academic acceptance lagged amid debates over mechanisms.

Takeaways

  • Nutrition is underemphasized in medical education relative to its potential impact on chronic disease.
  • Competing models (CICO vs. CIM) shape how clinicians and researchers interpret evidence and craft guidance.
  • More practical, patient-centered nutrition training and better translational frameworks are needed alongside pharmacologic options.

Papers referenced in the discussion (DOIs)

  • Carbohydrate-Insulin Model overview: Ludwig DS et al. “The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.” Am J Clin Nutr (2021). https://doi.org/10.1093/ajcn/nqab270
  • Statins & GLP-1 (human controlled trial): She J et al. “Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner.” Cell Metabolism (2024). https://doi.org/10.1016/j.cmet.2023.12.027
  • Low-carb/keto for T2D (Virta 2-year trial referenced): Athinarayanan SJ et al. “Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial.” Front Endocrinol (2019). https://doi.org/10.3389/fendo.2019.00348
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    2 months ago

    45:00 As a individual you don’t have to wait for the standard of care to change, you can take information and try it now… but for the masses…

    • Isabella Cooper — “Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females.” DOI: 10.3390/ijms242115621

    This was a really interesting paper they mentioned, they took longer term keto people, put them on high carb and recorded what happened!