A modern endemic of metabolic health
summerizer
Summary — “Insulin resistance with Dr. Dhand”
What insulin resistance is
- Insulin lowers blood glucose by signaling cells (via insulin receptors) to take in glucose.
- With frequent, repeated insulin spikes (e.g., constant snacking, high sugar/refined-carb eating), receptors become less responsive.
- The body compensates by secreting more insulin (hyperinsulinemia), which drives a vicious cycle.
- Insulin resistance typically develops years—sometimes decades—before fasting glucose or HbA1c rise.
Why it matters
- Linked to common chronic conditions, including heart disease, autoimmune conditions, some cancers, and widespread “everyday” illnesses.
- Chronically high insulin is pro-inflammatory and promotes fat storage and weight gain.
How to detect earlier (as discussed)
- Check fasting insulin alongside fasting glucose (not routinely done in many places).
- From fasting insulin and glucose, a calculation can be done to estimate insulin resistance (host notes people can find this online).
- Relying on fasting glucose/HbA1c alone detects the problem late in its course.
Major drivers (described)
- Dietary pattern: Excess refined carbohydrates and sugars; frequent eating/snacking leading to constant insulin spikes.
- Low activity/sedentary lifestyle.
- Poor sleep and chronic stress (cortisol discussed as a factor).
- Social/cultural shifts toward larger quantities of food and continuous eating.
Nutrition guidance (practical points given)
- Minimize carbs and sugars; aim to avoid constant grazing.
- Optimize protein intake: A general minimum target mentioned is ~1 g protein per kg body weight per day (example given: 75 kg person ≈ 75 g/day).
- Plate rule: “Half protein, half antioxidants,” where antioxidants are colorful vegetables.
- Plant protein options: Legumes (beans, peas, lentils), nuts, and seeds also provide fiber that supports the microbiome.
- Time-restricted eating: Many people succeed with a 6–8 hour eating window (e.g., first meal ~11–12, last meal ~18–19). Spend most of the day in a fasted state so insulin stays low; adapt gradually.
- Alcohol awareness: Track intake—people are often surprised by how high it is.
Physical activity (practical points given)
- Start moving even if currently inactive; walking is a valid starting point.
- Resistance/weight training is emphasized; alternate upper body, lower body, and core work. Even light weights help.
- Movement and training also reduce stress and improve other aspects of life.
Sleep & stress
- Going to bed slightly hungry can become tolerable as the body adapts to a restricted window.
- Use tools that lower cortisol and stress: exercise, meditation, warm bath, laughter/comedy, time with loved ones—whatever is personally effective.
- Small, repeatable “wins” build momentum and better habits.
Big-picture mindset
- Modern culture normalizes constant eating and ultra-processed, sugar-dense foods; reversing this requires intentional habits.
- Prioritize fundamentals (food quality/quantity, protein, vegetables, movement, sleep, stress management) and build small, sustainable wins.
You must log in or # to comment.
Of course they never go so far as to mention ketogenic metabolism, but it’s a good introduction for people who aren’t ready to learn about keto


