A modern endemic of metabolic health

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Summary — “Insulin resistance with Dr. Dhand”

What insulin resistance is

  • Insulin lowers blood glucose by signaling cells (via insulin receptors) to take in glucose.
  • With frequent, repeated insulin spikes (e.g., constant snacking, high sugar/refined-carb eating), receptors become less responsive.
  • The body compensates by secreting more insulin (hyperinsulinemia), which drives a vicious cycle.
  • Insulin resistance typically develops years—sometimes decades—before fasting glucose or HbA1c rise.

Why it matters

  • Linked to common chronic conditions, including heart disease, autoimmune conditions, some cancers, and widespread “everyday” illnesses.
  • Chronically high insulin is pro-inflammatory and promotes fat storage and weight gain.

How to detect earlier (as discussed)

  • Check fasting insulin alongside fasting glucose (not routinely done in many places).
  • From fasting insulin and glucose, a calculation can be done to estimate insulin resistance (host notes people can find this online).
  • Relying on fasting glucose/HbA1c alone detects the problem late in its course.

Major drivers (described)

  • Dietary pattern: Excess refined carbohydrates and sugars; frequent eating/snacking leading to constant insulin spikes.
  • Low activity/sedentary lifestyle.
  • Poor sleep and chronic stress (cortisol discussed as a factor).
  • Social/cultural shifts toward larger quantities of food and continuous eating.

Nutrition guidance (practical points given)

  • Minimize carbs and sugars; aim to avoid constant grazing.
  • Optimize protein intake: A general minimum target mentioned is ~1 g protein per kg body weight per day (example given: 75 kg person ≈ 75 g/day).
  • Plate rule: “Half protein, half antioxidants,” where antioxidants are colorful vegetables.
  • Plant protein options: Legumes (beans, peas, lentils), nuts, and seeds also provide fiber that supports the microbiome.
  • Time-restricted eating: Many people succeed with a 6–8 hour eating window (e.g., first meal ~11–12, last meal ~18–19). Spend most of the day in a fasted state so insulin stays low; adapt gradually.
  • Alcohol awareness: Track intake—people are often surprised by how high it is.

Physical activity (practical points given)

  • Start moving even if currently inactive; walking is a valid starting point.
  • Resistance/weight training is emphasized; alternate upper body, lower body, and core work. Even light weights help.
  • Movement and training also reduce stress and improve other aspects of life.

Sleep & stress

  • Going to bed slightly hungry can become tolerable as the body adapts to a restricted window.
  • Use tools that lower cortisol and stress: exercise, meditation, warm bath, laughter/comedy, time with loved ones—whatever is personally effective.
  • Small, repeatable “wins” build momentum and better habits.

Big-picture mindset

  • Modern culture normalizes constant eating and ultra-processed, sugar-dense foods; reversing this requires intentional habits.
  • Prioritize fundamentals (food quality/quantity, protein, vegetables, movement, sleep, stress management) and build small, sustainable wins.
  • jetOPMA
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    26 days ago

    Of course they never go so far as to mention ketogenic metabolism, but it’s a good introduction for people who aren’t ready to learn about keto