A very informative conversation between a researcher and a practicing clinician.

Dr. Matthew Phillips is a clinical and research neurologist and the director of neurology at Waikato Hospital, Hamilton, New Zealand. His foremost passion is to explore the potential feasibility, safety, and efficacy of metabolic strategies, particularly fasting and ketogenic diets, in creating alternate metabolic states that may benefit people with a variety of neurological disorders. His team conducted the world’s first randomized trials involving a ketogenic diet in people with both Parkinson’s and Alzheimer’s disease, as well as the first published application of a fasting and ketogenic diet protocol in people with amyotrophic lateral sclerosis and Huntington’s disease. He is currently conducting a clinical trial in glioblastoma, which combines standard treatments with the most intensive fasting and ketogenic diet protocol ever applied to a group of patients with advanced cancer.

metabolicneurologist.com x.com/drmclphillips

the paper they talk about https://pubmed.ncbi.nlm.nih.gov/35656107/

  • psud@aussie.zoneMEnglish
    2·
    4 hours ago

    Yeah this guy is the business. His Alzheimer’s experiment was two groups 12 weeks on dietician designed low fat for one group and 12 weeks on keto for the other group

    Then both groups go on normal diet for 12 weeks to clear any effects from the previous part

    Then they swap. The first group does keto for 12 weeks and the second follows the dietician’s low fat diet

    So each person had both treatments

    Note that there is no current treatment so you couldn’t really compare to the current standard of care

  • psud@aussie.zoneMEnglish
    2·
    5 hours ago

    Is dr Matt Phillips the one producing all those low carb papers? Motor neuron disease, MS, and the rest?

    And yes he is that person, he talks about it about 10 mins in

    One thing I like about his studies is they’re not keto vs. standard diet, it’s keto vs dietician designed perfect low fat diet

    So everyone does better, and the keto people do best

    • jetOPMAEnglish
      1·
      5 hours ago

      Not all of them, some of them, for humans. He has a active study going on in NZ with glioblastoma patients using a aggressive ketogenic and fasting protocol.

  • jetOPMAEnglish
    1·
    3 hours ago

    Notes:

    They speak about protective neuron health, via fatty acids and ketones.

    Ketones produce more energy per unit oxygen and produce LESS free radicals and LESS oxidative stress in the brain. This oxidative stress may be contributing to neurodegenerative disorders.

    Ketones are only one part, the main focus is on optimizing mitochondria biology. (The power house of the cell, cell free mitochondria)

    Lifestyle disorders, and NDDs, metabolic syndrome - Mainly due to damaged mitochondria function.

    From a mito centric point of view, our health is really about the health of our mitochondria.

    Attacking symptoms leaves systematic causes in place. The standard of care for lifestyle and NDDs is not great, you almost have to be your own advocate and doing your own research.

    Germ theory vs Terrain theory - If the host is healthy the germs don’t have much of a foothold to make you sick. We don’t need better medicine, we need better metabolic health.