TLDR: Nothing burger junk science paper we see pumped out every 3 months from the same observational food frequency questionnaires.

Findings In this cohort study of 221 054 adults from 3 large cohorts, higher butter intake was associated with increased total and cancer mortality, while higher intake of plant-based oils was associated with lower total, cancer, and cardiovascular disease mortality.

Meaning Substituting butter with plant-based oils, particularly olive, soybean, and canola oils, may confer substantial benefits for preventing premature deaths.

Conclusions and Relevance In this cohort study, higher intake of butter was associated with increased mortality, while higher plant-based oils intake was associated with lower mortality. Substituting butter with plant-based oils may confer substantial benefits for preventing premature deaths.

Full paper: https://doi.org/10.1001/jamainternmed.2025.0205

  • jetOPMAEnglish
    1·
    4 days ago

    Dr. Ken Berry goes over the paper as well: https://youtu.be/5unN0Tx87nY

    • Observational
    • Self reported
    • Cumulative Averages
    • Lack of Randomization
    • Residual confounding
    • Healthy user bias
    • Socioeconomic factors
    • Dairy and Butter not differentiated
    • Lack of control of components - didn’t isolate butter and oil intakes
    • All plant based oils grouped together
    • No differentiation between cooking and uncooked
    • Lack of consideration for industrial processing
    • Death Certificate Classification (bias in death certificates)
    • Cancer and cardiovascular assumptions
    • No analysis of omega 6 - vs omega 3
    • Very low hazard ratios, very weak association, not clinically association
    • Multiple comparisons without adjustment
    • Substitution model assumptions
    • Not generalizable (mostly white and health care professionals)
    • Significant conflict of interesting (Plant based bias from Harvard)