I took a brief look over the handbook, every chapter, and especially the chapters on nutrition and metabolism

I think there are some major gaps that a more updated version of the handbook should cover, such as the previously mentioned carbohydate-insulin model of obesity https://hackertalks.com/post/7617450

If you have time I would highly recommend the ketogenic handbook: the science of therapeutic carbohydrate restriction - https://shop.elsevier.com/books/ketogenic/noakes/978-0-12-821617-0 - it is also available online at the usual places.

While the text isn’t focused on obesity it makes a compelling through line between metabolic syndrome, hyperinsulinemia, and the conditions the obesity handbook has associated with obesity.

I did enjoy the opening quote about obesity: To treat obesity, Hippocrates, the “father of medicine,” suggested the following:

[o]bese people and those desiring to lose weight should perform hard work before food. Meals should be taken after exertion and while still panting from fatigue and with no other refreshment before meals except only wine, diluted and slightly cold. Their meals should be prepared with sesame or seasoning and other similar substances and be of a fatty nature as people get thus, satiated with little food. They should, moreover, eat only once a day and take no baths and sleep on a hard bed and walk naked as long as possible. - Precope J. Hippocrates on Diet and Hygiene. 1952.

In this quote we have :

• Eat fat to lose fat
• One Meal A Day (Intermittent Fasting / Time restricted Eating)
• cardio, and walking.